Our research activities benefit from the interplay between theory and application, and fall into two types:

  • Fundamental advances in the area of optimization theory, algorithms, and software.
  • Comprehensive solutions to important and fundamental problems involving biological, chemical, and engineering systems.

Our main research results have included:

Global Optimization

Developing an all-purpose, rigorous global optimization methodology for continuous, integer, and mixed integer nonlinear programs


Advanced informatics technology through chemical, biological, and medical sciences

Process Synthesis and Operations

Is it possible to introduce rigor in the use and practice of heuristics?